Multidrug Resistance Reversal in Cancer Through a Novel Allosteric Mechanism

PI Daniel José Viegas Antunes dos Santos

CBIOS team members

Patrícia Dias de Mendonça Rijo; Andreia de Almeida Rosatella; Vera Mónica Sousa Isca; Gabrielle Bangay; Pedro Suzano

Description

Multidrug resistance (MDR) is characterized by complex resistance mechanisms that protect cells from compounds with different chemical groups and modes of action. It is prevalent in all forms of cancer, one of the greatest health challenges present in modern society, as well as in drug-resistant bacteria and fungi.In this project, we intend to target the primary mediators of MDR in cancer (ABC transporter protein family) through a novel therapeutic approach and mechanism, recently discovered in the PI group.

Funded

ILIND/COFAC