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universidade lusófona

Projects

LusoModLOX: Lusophone flora fighting disease: focus on therapeutic lysyl oxidase modulators

PI Ana Sofia Fernandes

CBIOS Team Members

Patrícia Rijo, Catarina Rosado, Nuno Saraiva, João Costa,  Luís Monteiro Rodrigues, Catarina Leite, Tânia Almeida, Sérgio Andrade, Jaime Coelho, Sandra Ferreira, Sofia Ramos, Paulo Luz, Ana júlio, Epole Ntungwe, Vera Isca

From  2021 to 2024

Description

This project explores how plants from Portuguese-speaking regions could provide new treatments for wound healing and breast cancer. By investigating Lysil oxidase enzymes and their role in these conditions, the project aims to find natural compounds that can modulate LOX activity. These compounds will be tested on breast cancer cells and skin cells to understand their effects. Additionally, the project will use advanced techniques to enhance the effectiveness and safety of these natural compounds. This collaborative effort brings together experts from various fields to train young researchers and establish international partnerships for future progress.

Outputs

4 full papers (3 in Q1 and 1 in Q3 journals)

  • Ferreira, S., Rijo P., Costa, J. G., Saraiva N., Santos, B., Uriel, C., Goméz, A. M., Díaz-Lanza, A. M., & Fernandes, A. S. (2023) Evaluation of the Lysyl Oxidase-Like 2 (LOXL2) inhibitory activity of pimaranes and their glycosyl derivatives. Biomedical and Biopharmaceutical Research, 20(1), 1-12. https://doi:10.19277/bbr.20.1.305
  • Guerreiro, Í., Vidovic, B., Costa, J. G., Martins, M., Ferreira, S., Oliveira, N. G., Saraiva, N.*, & Fernandes, A. S.* (2023). The Dietary Isothiocyanate Erucin Reduces Kidney Cell Motility by Disturbing Tubulin Polymerization. Molecular nutrition & food research, 67(3), e2200581. https://doi.org/10.1002/mnfr.202200581
  • Ramos, S., Ferreira, S., Fernandes, A. S., & Saraiva, N. (2022). Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis. Frontiers in pharmacology, 13, 883998. https://doi.org/10.3389/fphar.2022.883998
  • Ferreira, S., Saraiva, N., Rijo, P., & Fernandes, A. S. (2021). LOXL2 Inhibitors and Breast Cancer Progression. Antioxidants (Basel, Switzerland), 10(2), 312. https://doi.org/10.3390/antiox10020312

Funding 

ILIND/COFAC - Fazer+: Excelência na Investigação

Reference: ILIND/F+/EI/01/2020