Establishment of safety properties and clinical efficacy of rosmarinic acid in Quality by design (QbD) -optimized dermocosmetic formulations

PI André Rolim Baby, Universidade de São Paulo, Brasil

CBIOS Team members 

Catarina Rosado
From 2019 to 2020

Description

The project was based on the application of the concepts of quality by design (QbD) and process analytical technology (PAT – Process Analytical Technology) to evaluate critical quality parameters and develop an optimized cosmetic formulation with rosmarinic acid. The formulations were developed using a factorial experimental design (DoE – Design of Experiments), characterized physically and physicochemically and evaluated for in vitro antioxidant activity and in vitro photoprotective efficacy, as well as for photostability. The formulations were also characterized for their photoprotective efficacy in vivo, as well as evaluated for their safety.

Partner Entities

Universidade de São Paulo, Brasil

CBIOS- Universidade Lusófona

Funding Entity

CAPES 88887.371188/2019-00