In this project we use a novel approach to tackle cancer by combining three molecular targets (p-glycoprotein, protein kinase C and the lysyl oxidase-like 2 enzime) and three synergistic scientific contributions (natural products isolation and identification, biological assays and computational chemistry) to improve upon natural products isolated in-house targeting ABC efflux transporters and PKC, and to develop novel molecular entities able to inhibit the LOXL2 enzyme known to contribute to tumor cell invasion by promoting cytoskeletal reorganization, as a combined strategy to tackle metastatic cancer and multidrug-resistance.
