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universidade lusófona
Research

Natural Bioatives & Circular Economy Lab

Head

Patricia Rijo

    

 

In the scientific domain of Natural Bioactives & Circular Economy, three main areas are prominent:

— Natural Bioactives, encompassing Natural Products chemistry, Extraction optimization, isolation, structural characterization, Molecular Design, Semi-synthesis of Bioactive Molecules & Structure-Activity Relationship studies, and Bioactives analysis and quantification using techniques like HPLC, GC, and FTIR analysis.

— Computational modeling, plays a pivotal role in discovering novel molecules, understanding the drug’s mode of action and development the molecule’s potency within a rational drug design framework and providing predictive models on various processes within this domain.

— Ionic Liquids, focusing on their synthesis and new applications, contributing to sustainable practices and circular economy initiatives.

Resources

Natural Products chemistry/isolation/purification/characterization

Several laboratory supplies, equipment, and bench space are available for carrying out common isolation and purification using chromatographic techniques including analytical and semi-preparative HPLC-DAD and BUCHI Chromatography.

GC-FID

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HPLC

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FTIR

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BUCHI Cromatography

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HPLC-DAD / FTIR / GC-FID

Routine chromatographic analysis for identification and quantification of polar and nonpolar compounds (only with standards available). Development, implementation and validation of HPLC-DAD / FTIR / GC-FID  methods

Integrated Antimicrobial Assessment Facilities for Diverse Samples

Screening Antimicrobial Activity via Wells Diffusion and Microdilution Methods Against Gram-Positive, Gram-Negative Bacteria, and Yeasts, Including Exploratory Studies on the Effects of Various Samples on Microorganism Growth Curves and Viability.

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 Comprehensive Synthesis and Characterization of Ionic Liquids

This state-of-the-art chemistry laboratory is dedicated to the comprehensive synthesis and characterization of ionic liquids, and other materials utilizing cutting-edge techniques to explore their distinctive properties. The laboratory is equipped with a sophisticated viscometer and a Karl Fischer titrator, among other instruments.

Karl Fisher

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Viscometer

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 High throuhgput virtual screening

 Hit to lead development and early drug discovery research

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Linux high throughput cluster and workstations with state-of-the-art NVIDIA GPUs: 3 workstations, 3 NVIDIA GPU, 56 core.

Network Attached Storage (NAS) (6x4 TB disks in raid 6 (up to 2 disks to fail); total capacity of 16 TB) and CBIOS NAS (4x12 TB RAID1: mirrored; total capacity of 24 TB)

 Translational Capacities and Services 

High throuput virtual screening campaigns

Lead optimization